Invasive pneumococcal disease surveillance, 1 July to 30 September 2016

This quarterly report describes surveillance of invasive pneumococcal disease in Australia during the 3rd quarter of 2016.

Page last updated: 24 December 2016

Rachael Corvisy, Jennie Hood and the Enhanced Invasive Pneumococcal Disease Surveillance Working Group, for the Communicable Diseases Network Australia

Summary

The number of notified cases of invasive pneumococcal disease (IPD) in the 3rd quarter of 2016 was substantially more than the previous quarter and marginally more than the number of notified cases in the 3rd quarter of 2015. Overall, the decline in disease due to the serotypes targeted by the 13-valent pneumococcal conjugate vaccine (13vPCV) has been maintained across all age groups since the 13vPCV replaced the 7-valent pneumococcal conjugate vaccine (7vPCV) in the childhood immunisation program from July 2011.

Key points

In the 3rd quarter of 2016, there were 637 cases of IPD reported to the National Notifiable Disease Surveillance System, an 8% increase when compared with the same period in 2015 (n=589) (Table 1). In the 3rd quarter of 2016 the most common pneumococcal serotypes causing IPD were 3 (8.9%), 9N (7.5%), 19A (6.1%) and 23A (6.0%) (Table 2). Compared with the 2nd quarter of 2016, there was a slight decrease in serotypes 3 (9.3%) and 19A (8.4%) and an increase in serotypes 9N (5.2%) and 23A (2.9%).

Table 1: Notified cases of invasive pneumococcal disease, Australia, 1 July to 30 September 2016, by Indigenous status, serotype completeness and state or territory
Indigenous status ACT NSW NT Qld SA Tas. Vic. WA Total 3rd qtr 2016 Total 2nd qtr 2016 Total 3rd qtr 2015
* Indigenous status completeness is defined as the reporting of a known Indigenous status, excluding the reporting of not stated or unknown Indigenous status.

† Serotype completeness is the proportion of all cases of invasive pneumococcal disease that were reported with a serotype or reported as non-typeable. Serotype incompleteness may include when no isolate was available as diagnosis was by polymerase chain reaction and no molecular typing was attempted or was not possible due to insufficient genetic material; the isolate was not referred to the reference laboratory or was not viable; typing was pending at the time of reporting, or no serotype was reported by the notifying jurisdiction to the National Notifiable Diseases Surveillance System.

Indigenous 0 11 11 19 5 0 0 26 72 32 63
Non-Indigenous 14 155 2 86 50 12 115 67 501 368 455
Not stated / Unknown 0 38 0 0 0 0 26 0 64 39 71
Total 14 204 13 105 55 12 141 93 637 439 589
Indigenous status completeness* (%) 100 81 100 100 100 100 82 100 90 91 88
Serotype completeness (%) 100 91 92 97 64 92 89 94 90 93 93

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Table 2: Distribution of serotypes causing invasive pneumococcal disease in notified cases, Australia, 1 July to 30 September 2016, by age group
Serotype Age groups Serotype total
Under 5 years 5–64 years Over 65 years
* Serotypes that only occur in less than 5 cases per quarter are grouped as 'Other' and include 'non-typeable' isolates this quarter.

† 'Serotype unknown' includes those serotypes reported as 'no isolate', 'not referred', 'not viable', 'typing pending' and 'untyped'.

3 9 26 22 57
9N 3 32 13 48
19A 4 20 15 39
23A 2 14 22 38
22F 20 17 37
19F 4 15 16 35
6C 1 7 22 30
23B 4 12 10 26
8 22 4 26
15A 2 9 11 22
11A 2 10 8 20
33F 2 13 4 19
16F 9 9 18
35B 3 5 9 17
7F 15 2 17
15B 1 4 6 11
17F 1 8 2 11
10A 1 5 4 10
24F 2 2 4 8
31 4 4 8
15C 2 1 4 7
38 1 2 4 7
9V 6 1 7
10F 1 5 6
24 2 1 2 5
35F 1 1 3 5
4 4 1 5
7C 1 1 3 5
Unknown 21 34 10 65
Other 3 15 10 28
Total 73 322 242 637

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In non-Indigenous Australians, the number of notified cases was highest in children aged less than 5 years and older adult age groups, especially those aged 60 years or over (Table 3). In Indigenous Australians, cases were highest in children aged less than 5 years and the 40–44 years age group. The proportion of cases reported as Indigenous this quarter (11%; 72/637) was the same as that observed in the 3rd quarter of 2015 (11%; 63/589), and higher than the proportion reported in the 2nd quarter of 2016 (7%; 32/439).

Table 3: Notified cases of invasive pneumococcal disease, Australia 1 July to 30 September, by Indigenous status and age group
Age group Indigenous status Total
Indigenous Non-Indigenous Not reported*
* Not reported is defined as not stated or unknown Indigenous status.
00–04 12 60 1 73
05–09 2 16 3 21
10–14 8 1 9
15–19 4 5 2 11
20–24 3 7 2 12
25–29 1 6 8 15
30–34 7 13 7 27
35–39 3 15 7 25
40–44 10 9 11 30
45–49 5 11 7 23
50–54 3 33 2 38
55–59 7 32 1 40
60–64 6 60 5 71
65+ 9 226 7 242
Total 72 501 64 637

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In children aged less than 5 years, there were 73 cases of IPD reported, representing 11% of all cases reported in this quarter. The number of cases notified in this age group was slightly higher in this reporting period when compared with the 3rd quarter of 2015 (10%; 58/589). Of those cases with known serotype, 35% (18/52) were due to a serotype included in the 13vPCV compared with 50% (22/44) of cases in the 3rd quarter of 2015 (Figure 1). Serotypes 3, 19A, 19F and 23B were the most common serotypes affecting this age group in this quarter, noting that serotype 3, 19A and 19F are included in the 13vPCV (Table 2).

Figure 1: Notifications and annual rates* of invasive pneumococcal disease in children aged less than 5 years, Australia, 2007 to 30 September 2016, by vaccine serotype group

line and bar chart. Text description follows.

* Annual rates are shown on Q2, excluding 2016.

Text version of Figure 1 (TXT 1 KB)

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In the 3rd quarter of 2016, there were 10 cases reported in fully vaccinated children aged less than 5 years who were considered to be 13vPCV failures. Serotype 19A was the most common serotype associated with 13vPCV failure reported this quarter (n=4), followed by serotypes 3 and 19F (n=3 each; Table 4).

Table 4: Characteristics of 13vPCV failures in children aged less than 5 years, Australia, 1 July to 30 September 2016
Age Indigenous status Serotype Clinical category Risk factor/s
7 months Indigenous 19A Other, septic arthritis No data available
1 year Indigenous 19A Bacteraemia No data available
1 year Non-Indigenous 19F Unknown No risk factor identified
1 year Non-Indigenous 19F Bacteraemia No data available
2 years Non-Indigenous 3 Pneumonia No data available
2 years Non-Indigenous 3 Pneumonia Other
2 years Non-Indigenous 19A Pneumonia No risk factor identified
2 years Non-Indigenous 19F Pneumonia Premature (<37 weeks gestation), Chronic Illness, Childcare attendee
3 years Indigenous 19A Bacteraemia Immunocompromised, Chronic illness, Other
4 years Non-Indigenous 3 Pneumonia No risk factor identified

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Among Indigenous Australians aged 50 years or over, there were 25 cases of IPD reported this quarter. Of those cases with a reported serotype, 61% (14/23) were due to a serotype included in the 23-valent polysaccharide pneumococcal vaccine (23vPPV) (Figure 2). The number of notified cases of IPD in this age group increased by 32% compared with the number reported in the previous quarter (n=19) and the 3rd quarter of 2015 (n=19). Compared with the previous quarter, the proportion of cases due to serotypes included in the 23vPPV decreased from 72% to 61% among cases with a known serotype. The most common serotypes causing disease in this group this quarter were serotypes 3 and 8 (n=3 each); these serotypes are included in the 23vPPV.

Figure 2: Notifications and annual rates* of all invasive pneumococcal disease in Indigenous Australians aged 50 years or over, Australia, 2007 to 30 September 2016 by vaccine serotype group

line and bar chart. Text description follows.

* Annual rates are shown on Q2, excluding 2016.

Text version of Figure 2 (TXT 1 KB)

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Among non-Indigenous Australians aged 65 years or over there were 233 cases of IPD reported this quarter. The number of notified cases of IPD in this age group increased by 46% when compared with the previous quarter (n=160) but was similar to the number reported in the 3rd quarter of 2015 (n=222). Of those cases with a reported serotype, 51% (113/222) were due to a serotype included in the 23vPPV (Figure 3), which was a small reduction when compared with the previous quarter (58%). For this quarter, serotypes 6C (n=22), 3 (n=21) and 23A (n=21) were the predominant serotypes for this population group.

Figure 3: Notifications and annual rates* of all invasive pneumococcal disease in non-indigenous Australians aged 65 years or over, Australia, 2007 to 30 September 2016 , by vaccine serotype group

line and bar chart. Text description follows.

* Annual rates are shown on Q2, excluding 2016.

† Non-Indigenous Australians includes cases reported with as non-Indigenous, not stated, blank or unknown.

Text version of Figure 3 (TXT 1 KB)

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During this quarter there were 49 deaths attributed to a variety of IPD serotypes. Of these deaths, 44 occurred in non-Indigenous Australians, with a median age of 69 years (range 0–95 years). A total of 5 deaths occurred in Indigenous Australians. There were 2 deaths reported in children less than 5 years of age, which were associated with serotype 6C and serotype 11A. One of these cases was under the age of 2 months and therefore not eligible for vaccination.

Notes

The data in this report are provisional and subject to change as laboratory results and additional case information become available. More detailed data analysis of IPD in Australia and surveillance methodology are described in the IPD annual report series published in Communicable Diseases Intelligence.

In Australia, pneumococcal vaccination is recommended as part of routine immunisation for children, individuals with specific underlying conditions associated with increased risk of IPD and older Australians. More information on the scheduling of the pneumococcal vaccination can be found on the Immunise Australia Program website (www.immunise.health.gov.au).

In this report, a ‘vaccine failure’ is where a fully vaccinated child is diagnosed with IPD due to a serotype covered by the administered vaccine. ‘Fully vaccinated’ describes cases that have completed the primary course of the relevant vaccine(s) required for their age according to the most recent edition of The Australian Immunisation Handbook, at least 2 weeks prior to disease onset with at least 28 days between doses of vaccine. NB: A young child who has had all the required doses for their age but is not old enough to have completed the primary course would not be classified as fully vaccinated.

There are 3 pneumococcal vaccines available in Australia, each targeting multiple serotypes (Table 5). Note that in this report serotype analysis is generally grouped according to vaccine composition.

Table 5: Streptococcus pneumoniae serotypes targeted by pneumococcal vaccines
Serotypes 7- valent pneumococcal conjugate vaccine (7vPCV) 10-valent pneumococcal conjugate vaccine (10vPCV) 13-valent pneumococcal conjugate vaccine (13vPCV) 23-valent pneumococcal polysaccharide vaccine (23vPPV)
1   y y y
2       y
3     y y
4 y y y y
5   y y y
6A     y  
6B y y y y
7F   y y y
8       y
9N       y
9V y y y y
10A       y
11A       y
12F       y
14 y y y y
15B       y
17F       y
18C y y y y
19A     y y
19F y y y y
20       y
22F       y
23F y y y y
33F       y

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Follow-up of all notified cases of IPD is undertaken in all states and territories except New South Wales and Victoria who conduct targeted follow-up of notified cases aged under 5 years, and 50 years or over for enhanced data. Follow-up in notified cases of IPD is undertaken in Queensland in all areas except Metro South and Gold Coast Public Health Units who conduct targeted follow-up of notified cases for those aged under 5 years only.

Acknowledgements

Report prepared with the assistance of Mark Trungove on behalf of the Enhanced Invasive Pneumococcal Disease Surveillance Working Group.

Enhanced Invasive Pneumococcal Disease Surveillance Working Group contributors to this report include (in alphabetical order): Frank Beard (NCIRS), Heather Cook (NT and secretariat), Lucinda Franklin (Vic.), Carolien Giele (WA), Robin Gilmour (NSW), Michelle Green (Tas.), Sanjay Jayasinghe (NCIRS), Vicki Krause (Chair), Shahin Oftadeh (Centre for Infectious Diseases and Microbiology- Public Health, Westmead Hospital), Sue Reid (ACT), Vitali Sintchenko (Centre for Infectious Diseases and Microbiology- Public Health, Westmead Hospital), Helen Smith (Queensland Health Forensic and Scientific Services), Janet Strachan (Microbiological Diagnostic Unit, University of Melbourne), Hannah Vogt (SA), Angela Wakefield (Qld).

Author details

Corresponding author: Rachael Corvisy, Vaccine Preventable Diseases Surveillance Section, Office of Health Protection, Australian Government Department of Health, GPO Box 9484, MDP 14, Canberra, ACT 2601. Telephone: +61 2 6289 1273. Facsimile: +61 2 6289 1070. Email: vpds@health.gov.au

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